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Vitamin a deficiency and infection with human immunodeficiency virus: What is the epidemiological evidence?

Identifieur interne : 001304 ( Main/Exploration ); précédent : 001303; suivant : 001305

Vitamin a deficiency and infection with human immunodeficiency virus: What is the epidemiological evidence?

Auteurs : Sonya Re Lejeune [Royaume-Uni] ; David Ross [Royaume-Uni] ; Prakash S. Shetty [Royaume-Uni]

Source :

RBID : ISTEX:A34710FEEF98602D5420FCBA01EC2D49FB6AC33D

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English descriptors

Abstract

Infection with human immunodeficiency virus (HIV) results in acquired immunodeficiency syndrome (AIDS), which is associated with increased vulnerability to opportunistic infections. Vitamin A has been shown to have immunostimulatory effects and the possible mechanisms for this include an increased resistance to the initial infection, increased ability to combat infection, and inhibition of viral replication. Although little work has been done on the relationship between vitamin A status and HIV AIDS, it is possible that vitamin A deficiency could increase the infectivity of the virus among high risk groups and/or increase the rate of progression of HIV infection and the development of AIDS. The available evidence relating to this has been reviewed here. One of the problems with the study of this relationship is that the validity of standard methods of assessment of vitamin A status within the HIV infected population is unclear. Serum retinol and possibly relative dose response results may be affected both by the presence of the HIV and the associated opportunistic infections. Biochemical tests of vitamin A status and dietary assessments of intake may also be affected by changes in the consumption of food as well as dietary supplements in individuals with the HIV infection.

Url:
DOI: 10.1016/0271-5317(96)00150-9


Affiliations:


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<div type="abstract" xml:lang="en">Infection with human immunodeficiency virus (HIV) results in acquired immunodeficiency syndrome (AIDS), which is associated with increased vulnerability to opportunistic infections. Vitamin A has been shown to have immunostimulatory effects and the possible mechanisms for this include an increased resistance to the initial infection, increased ability to combat infection, and inhibition of viral replication. Although little work has been done on the relationship between vitamin A status and HIV AIDS, it is possible that vitamin A deficiency could increase the infectivity of the virus among high risk groups and/or increase the rate of progression of HIV infection and the development of AIDS. The available evidence relating to this has been reviewed here. One of the problems with the study of this relationship is that the validity of standard methods of assessment of vitamin A status within the HIV infected population is unclear. Serum retinol and possibly relative dose response results may be affected both by the presence of the HIV and the associated opportunistic infections. Biochemical tests of vitamin A status and dietary assessments of intake may also be affected by changes in the consumption of food as well as dietary supplements in individuals with the HIV infection.</div>
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